STUDIES ON SODIUM COLISTIN METHANE SULFONATE (CL-M)
ON METABOLISM IN THE URINE AND BILE OF RABBITS
1976 Volume 24 Issue 8 Pages 1592-1596
Details
1976 Volume 24 Issue 8 Pages 1592-1596
Following intravenous injection of sodium colistin methane sulfonate (CL-M) in male rabbits, the 24 hours urinary and biliary recovery of CL-M was examined by bioassay.
Further 24 hours urinary and biliary metabolite of CL-M and that recovery was examined by TLC, NRP, and column chromatography.
The results obtained were as follows.
1) CL-M was excreted about 75% in the urine and slightly in the bile within 24 hours after administration.
2) As metabolite, colistin-N-glucuronide was found on the average of 1. 7% in the urine and 6. 7% in the bile, respectively, within 24 hours after administration.
