ABSORPTION AND EXCRETION OF PIVMECILLINAM IN THE PATIENTS WITH IMPAIRED RENAL FUNCTION
1977 Volume 25 Issue 1 Pages 284-288
Details
1977 Volume 25 Issue 1 Pages 284-288
On ten volunteers with reduced kidney function, 146.2mg pivmecillinam (equimolar to 100 mg mecillinam) was administered orally for the single dose study and given orally in a dose of 146.2mg q. i. d. for 7 days for the multiple dose study. The patients were divided into three groups according to their kidney functions. The level of mecillinam in serum or urine after dosing of pivmecillinam was compared between the three groups or the studies, and the following results were obtained.
1) In the patients with severe renal insufficiency, who had the level of creatinine clearance less than 30 ml/min, higher mecillinam blood level of greater duration than that of the patients in the other two groups was recognized.
2) The average of urinary concentration and of recovery from urine decreased in company with thelowering of their kidney functions, but the difference between the groups or the studies was statisticallynot significant.
3) In the patients with mild and moderate renal insufficiency, urinary concentration more than the level, necessary to heal urinary tract infections, was expected.
