1977 Volume 25 Issue 1 Pages 339-346
Basic and clinical studies on pivmecillinam were performed in the field of obstetrics and gynecology to give the following results.
1. Antibacterial activities of mecillinam against clinically isolated E. coli and Klebsiella were determined in comparison with ampicillin. With inoculum size of 108 cells/ml, mecillinam showed as potent antibacterial activities as ampicillin did. While, with inoculum size of 106 cells/ml, mecillinam was more potent than ampicillin.
2. Healthy adults and pregnant women were orally given pivmecillinam. Peak plasma mecillinam level in healthy adults appeared one hour after a 100 mg dose. Mecillinam was proved to transfer into umbilicalcord blood. The antibiotic was detected also in amniotic fluid when given continually.
3. Forty-eight patients with urinary-tract infections or intra-pelvis infections were given pivmecillinam and 81.2% of the patients responded to therapy. No noteworthy side effects were observed except slight gastrointestinal disturbances in 2 cases.