Abstract
1) Antibacterial activity
The antibacterial activity against Staphylococcus aureus of this drug seems to be slightly weak than that of ABPC and CBPC, but the antibacterial activity against gram negative bacilli, especially Klebsiella pneumoniae, Escherichia coil, Proteus, Pseudomonas aeruginosa and Serratia was more powerful than that of ABPC and CBPC.
2) Concentrations in blood and sputum
The peaks of the drug were observed at 30 min after intramuscular or intravenous administration of 1 g and at 2 hr after drip infusion and the levels were 27, 50 and 130μg/ml, respectively.
The concentrations in sputum were very different individually and dose response following the dosis of administration was not found and usually it was less than 2 μg/ml.
3) Clinical results
This drug was used for 20 cases of acute and chronic respiratory infectious diseases and 2 remarkably effective cases, 12 effective cases, 1 fairly effective case, 3 ineffective cases and 2 unknown cases of effectiveness were observed.
Especially any side effect was not observed, except that one case complaining of itching sensation accompanying with rash during instillation was observed and the administration had to stop.
