Abstract
Studies on the appropriate administration method of T-1220 against infectious diseases by Pseudomonas as the object, were carried out employing CBPC as the control drug.
1) Pseudomonas injured by T-1220 and CBPC disunited and reproduced in vitro and in vivo immediately, if the drug were removed.
2) It was demonstrated that total amount of administration of T-1220 was smaller than that of CBPC when T-1220 were administered by the method of multiple injection than by single administration.
3) The minimal effective concentrations of both drugs in vivo seemed to be almost essentially same to that in vitro.
4) The factors influencing the effect of treatment of both drugs were found to be total maintaining hours of the effective concentration in vivo.
5) When the duration of treatment were set to certain days, the more the times of administration increase the total administration dose required to the treatment decreased.
