Abstract
Distribution, fate and excretion of T-1220, which is effective against severe infections by gram-negative bacilli, were investigated.
Rats were intravenously or intramuscularly injected T-1220 in a dose of 20 mg/kg. Biological half lives of T-1220 in rat serum were 5.72 min and 7.54 min, respectively. Biological half life of T-1220 in the injected site of muscle was 4.11 min. The levels in kidney and liver were higher than the serum level. The high level in duodenum was also observed. The total amount excreted in 24 hr urine of the rat was 22% of the injected amount. The cord blood levels were 32.46 to 76.19% of maternal serum levels in the pregnant rats. The fetal liver level was higher than other organ levels. The amniotic level was low. Approximately 30% of T-1220 was bound to serum proteins.
