Abstract
The serum protein binding extent of T-1220 was determined by ultracentrifugation, centrifugal ultrafiltration and equilibrium dialysis techniques. Not a remarkable difference was observed in the binding extent among species. They were 21.2% in human, 24.0% in dog, 27.5% in rabbit and 24.8% in rat, respectively. The binding of T-1220 was reversible and not so fixative. The transitional activity to the focus of inframmatic was studied on the experimental model and the activity of T-1220 was compared to that of the other drugs. The result shows that the transitional activity to the focus of T-1220, having low protein binding extent, is higher than that of MPIPC having higher protein binding extent.
