1977 Volume 25 Issue 7 Pages 1921-1926
Laboratory and clinical studies on KW-1062, a new aminoglycoside antibiotic, were carried out and the following results were obtained :
1. Serum levels of KW-1062 were measured in healthy adults and aged patients given 60 and 40 mg of KW-1062 following single administration. Serum levels of KW-1062 were 5. 27 and 5. 9 μg/ml, respectively, after one hour. Both peak levels were similar. However, its excretion in urine varied according to renal functions of the patients.
2. KW-1062 was given to 17 cases at a dose of 40 mg twice a day. All the cases were aged. Clinical results were good in 13 cases and unknown in one case. Good results were obtained in 4 cases, where no response had been observed to other antibiotics.
3. As side effects, vertigo and headache were observed in each one case. The administration had been stopped because of their side effects. No other abnormality was observed in biochemical tests.
