PHARMACODYNAMIC STUDIES OF DOXYCYCLINE IN PATIENTS WITH COMPLCATED URINARY TRACT INFECTION ASSOCIATED WITH RENAL DYSFUNCTION

Abstract

On 6 patients with reduced renal function, single dose study that was administered 100 mg of doxycycline and multiple dose study that was administered 100 mg daily for 7 days by the route of intravenous drip infusion were carried out. The patients were divided into 2 groups according to their renal function; in the moderate renal dysfunction group (5 patients) their endogenous creatinine clearance were between 30 and 60 ml/mm. and in the severe renal dysfunction (one patient) that was under 30ml/mm.
After 100mg dosing, the mean serum peak levels were 2.33μg/ml in moderate renal dysfunction group and 3.40μg in severe renal dysfunction respectively. After multiple dosing the drug tended to accumulate in severe renal dysfunction, and the mean serum peak level on 7 th day were 2.96μg/ml in moderate renal dysfunction group and 6.60μg/ml in severe renal dysfunction, respectively. The mean time of half life in single dose study was 4.9 hours, and in multiple dose study those were 7.0 hours in moderate renal dysfunction group and 34.1 hours in severe renal dysfunction, respectively.
The mean peak urine levels were 18.6μg/ml for single dose study in moderate renal dysfunction group, and those were 0.6μg/ml and 3.8μg/ml in severe renal dysfunction, respectively.