Abstract
For the purpose of investigating reactions of toxicity of PC-, 904 when it was one-shot injected intravenously (iv), 500mg or 1000 mg of the drug were infused iv with 2 or 4 min. respectively into healthy adult men.
Clinical signs were observed by checking blood pressure, electrocardiogram, peripheral blood analysis, blood chemistry and urine tests before and after the administration.
As the results, no abnormal changes were noted in blood pressure, heart rate and electrocardiogram., Other laboratory findings also did not reveal any abnormalities.
From these data, it is believed that PC-904 does not affect any detectable toxicity on various kinds of organs' functions including circulatory system, when the drug is administered by iv one-shot with the above mentioned dosage and infusion speed.
The abstract of this paper was presented at the 25 th Congress of Chemotherapy (Japan Society of Chemotherapy), New Drug Symposium, Gifu, June 1977.
