Abstract
Clinical application of the semi-synthesized penicillin, PC-904, led to the following results.
1) MICs of PC-904 were lower than those of CBPC or SBPC against E. coil, Klebsiella and Pseudo-monas aeruginosa.
2) The effect of PC-904 on 21 infectious diseases in the field of internal medicine was considered excellent or good in 13 cases (61.9%).
3) The bacteriological effects revealed that 11 (68.8%) of 16 strains were converted negatively or decreased.
4) As far as side effects were concerned, skin rash or anorexia were observed in 5 cases, though these symptoms were eliminated by the withdrawal of, drug in all cases.
5) Because PC-904 has powerful antibacterial effects and is characterized by the excellent transdiffusion into liver and bile, this drug seems to be a useful antibiotic if application is selected prudently.
