Abstract
In vitro and in vivo antibacterial activity of PC-904, broad spectrum, semisynthesized penicillin, were examined, and it was revealed that the drug has a strong activity against various strains of gram-negative bacilli.
1) The effect of therapy with PC-904 was better than with either SBPC or T-1220 against P.aeruginosa when in vivo experiments with challenge by a large inoculum or small inoculum were applied.
2) It was revealed that PC-904 had marked antibacterial activity in vitro or in vivo even on gentamicin-resistant Pseudomonas aeruginosa.
3) Against Serratia, PC-904 was ineffective, though other conventional drugs were susceptible.
4) PC-904 was revealed to be effective in vitro on glucose non-fermentation gram-negative bacilli which were resistant to conventional antibiotics.
