Abstract
PC-904, a new semisynthetic penicillin, was investigated on its serum level, bile level, clinicaleffectiveness and side effects.
1) Following drip infusion either 1 or 1. 5g PC-904 in 4 patients, the serum level showed a peakat one hour and continued high level at 6 hours after the intravenous drip infusion, but the bileshowed no definite distribution of the drug.
2) PC-904 was given to 30 patients with various infections in the field of surgery. Clinical responsesevaluated in 6 patients with biliary tract infections were excellent and good in each 3 cases, excel-lent in 4 cases, good in 4 cases and fair in 1 case among 9 ones with peritonitis, excellent in 4 cases, good in 3 cases and poor in 1 case among 8 ones with periproctal infections (efficacy rate 87.5%), and excellent in 2 cases, good in 3 cases, fair in 1 case and poor in 1 case among 7 ones withthe other infections (efficacy rate 85. 7%). Totally efficacy rate was 93.3%.
No side effects were noted. Abnormal elevations in serum and urine amylase unit were noted inone case, though these were reversible.
