1979 Volume 27 Issue Supplement2 Pages 153-159
Cefsulodin (SCE-129, CFS), a new antipseudomonal cephalosporin preparation has been investigated to give following results.
1) Insusceptibility test of 315 strains of P. aeruginosa isolated from clinical specimens using plate dilution method, 71.4% of strains were inhibited by 25μg/ml of the drug. Sensitivity distribution curve of these strains showed 2 peaks.
Correlation coefficients between MICs of the drug and Apalcillin (APPC) and Piperacillin (PIPC) were 0.568 and 0.515 respectively, suggesting no strong cross-resistances between these drugs.
2) Absorption and excretion study following 250 mg i. m. administration was carried out on patients in advanced age. In 5 cases without serious renal or hepatic impairment, mean peak level of 3.86±0.46μg/ml and mean urinary recovery of 52.0±3.8% were obtained and worked out mean half life was about 3.0 hour, whereas in a case with moderate ienal failure, prolonged serum concentration and poor urinary excretion were obtained.
3) In clinical evaluation in 11 patients with Pseudomonas infections including 4 respiratory and 7 urinary tract infection, 4 responded favourably, 4 showed fair, and 3 poor results. Most patients were in advanced age and had underlying diseases. Bacterial replacements or relapse have occurred in 5 cases. There were no abnormal fluctuation of laboratory values except in one case with renal impairment with increase in BUN and S-Cr values after the treatment.
