1979 Volume 27 Issue Supplement7 Pages 250-258
Fundamental and Clinical studies on cefaclor, a new oral cephalosporin antibiotic, were performed, and following results were obtained.
1) Antibacterial activity
Cefaclor was more active than CEX against E. coli, Klebsiella pneumoniae, Proteus mirabilis and Haemophilus influenzae.
2) Absorption and excretion
Concentrations of cefaclor in serum and urine after single oral administration of 250mg were measured of 6 male healthy adult volunteers in a cross over method at a time of fasting and non fasting.
The mean peak concentrations in serum were 5μg/ml at 30 minutes in fasting cases, and 2.2μg/ml at 2 hours in non fasting cases. The influence of meal was appearent from blood levels of cefaclor.
And the mean urinary recovery during the first 6 hours of administration was 78.7% in fasting cases and 68.0% in non fasting cases.
3) Clinical results
Cefaclor was administered in 19 patients of various infections. The therapeutic effect of the drug was estimated as good in 14 cases, fair in 2 cases and poor in 3 cases. The efficacy rate was 73.7%. Particularly in the group of 6 cases with secondary infection of pulmonary emphysema and bronchiectasis, the effect was good in 1 case, fair in 2 cases and poor in 3 cases.
No side effect was seen.
