Abstract
A dialysis cell unit was used in conjunction with our previously described kinetic model for simulating antibiotic concentrations in exudates and tissues.
The bactericidal efficacy of cefazol in in the dialysis cell was investigated in the model simulating the serum levels in the flow cell after i. v. dosing with 0.25 to 2g. In this experiment, the activity of cefazolin was dose-dependent in the range of the drug concentrations used. When 5 strains of E. coli (MIC:3.13-50μg/ml) were used as the test organism, the bactericidal eficacy of cefazolin correlated well with the drug concentrations in the dialysis cell.
