BACTERIOLOGICAL EVALUATION OF CEFOTAXIME, A NEVI CEPHALOSPORIN, ANTIBIOTIC
1980 Volume 28 Issue Supplement1 Pages 42-64
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1980 Volume 28 Issue Supplement1 Pages 42-64
The in vitro and in vivo antibacterial activity of cefotaxime was compared with that of cefazolin and cefmetazole. The following results were obtained,
1) Cefotaxime showed broad antibacterial spectrum against gram-positive and gram-negative bacteria.
2) hi the sensitivity distribution to clinical isolates cefotaxime exhibited stronger antibacteria activity than cefazolin and cefmetazole against not only Streptococcus pyogenes, Streptococcus pneumimiae, Noisseria gonorrhoeae, Escherichia coli, Klebsiella pneumoniae and Proteus mirabilis but also most strains of cephalo Sporin-resistant Escheriehia coli, Klebsiella pneumoniae, indole-positive Proteus sp., Serratia marcescens and Pseudoinonas aeruginosa, while slightly inferior to those of cefazolin and cefmetazole against Staphylococcus aureus.
3) Cefotaxime was bacteoicidal against Escherichia coli, Klebsiella pneumoniae, Serra Serratia marcescens and Pseudoinonas aeruginosa at concentrations generally equal to or only two fold higher than the minimum inhibitory concentration.
4) Cefotaxime was more effective than cefazolin and cefmetazole in experimental mice infections caused by giam-negative bacteria, including Proteus vulgaris, Proteus morganii, Serratia marcescens and Pseudomonas aeruginosa.
