EXPERIMENTAL AND CLINICAL STUDIES OF CEFADROXIL IN THE TREATMENT OF INFECTIONS IN THE FIELD OF OBSTETRICS AND GYNECOLOGY

Abstract

Cefadroxil, a new semisynthetic antibiotic, was studied on its antibacterial activity, penetration into umbilical cord serum, and clinical efficacy.
These studies were carrid out in the patients of acute cystitis after gynecologic operation, and the following results were obtained.
1) Cefadroxil was similarly effective to cephalexin (CEX) against Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Proteus mirabillis and Proteus vulgaris.
2) Cefadroxil was distributed longer than other antibiotics in umbilical cord serum.
3) Cefadroxil was distributed better than other antibiotics in umbilical cord serum, amniotic fluid and newborn blood.
4) Cefadroxil was a little excreted in maternal milk.
5) Cefadroxil was administered clinically at a daily dose of 750mg to 1 case of acute simple cystitis and 10 cases of acute cystitis after gynecologic operation. Clinical efficacy obtained was excellent in 4 cases and good in 4 cases.
As the bacteriological efficacy, organisms were eliminated in 7 cases and decreased in 2 cases.
As to the side effect of the drug, GOT and GPT values were elevated in 1 case, and rash and itching appeared to in another 1 case, though both patients returned to normal after discontinuation of the administration.