STUDIES ON CEFTIZOXIME (CZX)
1980 Volume 28 Issue Supplement5 Pages 232-238
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1980 Volume 28 Issue Supplement5 Pages 232-238
Laboratory and clinical studies on CZX, a new cephalosporin antibiotic, were carried out and the following results were obtained.
1. Clinical gram-negative isolates tested against CZX showed far superior susceptibilitiy to CEZ in special reference to E. coli, Klebsiella and Proteus.
2. CZX was administered in doses of one and two grams to six healthy male adults by drip infusion over two hours. Two grams of CEZ were also given in cross over method.
Dose response was found between the serum levels obtained in one and two grams of CZX administration.
Serum levels of CZX after two grams drip infusion were lower and the elimination from serum was faster than those of CEZ. Both recovery rates from urine and urinary levels of CZX were higher.
Serum levels, and biliary and urinary excretion of CZX were determined following intramuscular injection in dose of 40mg/kg to three normal rats. Both of rates of biliary and urinary excretion were considered to be satisfactorily high.
3. Clinically, one patient with biliary tract infection was treated with CZX, and responded well, without showing any side effect.
