1980 Volume 28 Issue Supplement6 Pages 131-144
In vitro and in vivo antibacterial activity of cefoperazone (CPZ, T-1551) have been carried out, and the following results were obtained:
1) CPZ showed broad antibacterial spectrum against gram-positive and gramnegative bacteria.
2) The in vitro antibacterial activity of CPZ against clinical isolates of Serratia sp., indole (+) Proteus, Enterobacter sp. and Pseudomonas sp. was found to have more effective than cefazolin (CEZ) and cephalothin (CET).
3) Bactericidal activity of CPZ was studied, minimum bactericidal concentration (MBC) was almost the same as its minimum inhibitory concentration (MIC).
4) Antibacterial activity of CPZ was not affected by the change of pH and media, and addition of human serum to culture media.
5) Stability to β-lactamase extracted from penicillin and cephalosporin resistant clinical isolated bacteria was demonstrated. CPZ was very stable than CEZ and CET against cephalosporinase, and was similar to CEZ and CET against penicillinase.
6) On the protecting effects for systemic infections of various bacteria in mice, CPZ was more active than CEZ.
