COMBINED ACTION OF CEFOPERAZONE (T-1551) AND VARIOUS ANTIBIOTICS AGAINST SERRATIA MARCESCENS AND PSEUDOMONAS AERUGINOSA

Abstract

The in vitro and in vivo synergistic activities of cefoperazone (CPZ, T-1551) and aminoglycosides, macrolides, or tetracycline against, clinical isolates of Serratia marcescens and Pseudomonas aeruginosa were studied.
The combinations of CPZ and aminoglycosides (gentamicin, amikacin, tobramycin, dibekacin) showed markedly synergistic activity in both in vitro antibacterial activity against S. marcescens and P. aeruginosa and protective effects on experimental infection in mice. And the combined actions were bactericidal.
On the other hand, in vitro combinations of CPZ and macrolides (kitasamycin, lincomycin, erythromycin) or tetracycline showed rather weak synergism.