1980 Volume 28 Issue Supplement6 Pages 316-321
The minimal inhibitory concentrations (MIC) of cefoperazone (CPZ, T-1551) was measured against S. aureus, E. coli, K. pneumoniae, Proteus, S. marcescens and P. aeruginosa isolated from clinical materials. CPZ was administered to 23 cases of respiratory tract infections and 1 case of cholecystitis and 2 cases of urinary tract infections (UTI).
1) The MIC values of CPZ against over each 50% of strains of S. aureus, E. coli and K. pneumoniae were less than 1.56μg/ml, 50% of strains of Proteus was less than 3.13μg/ml, while about each 30% of strains of S. marcescens and P. aeruginosa were less than 6.25μg/ml.
2) Excellent clinical response was obtained in 2 cases of pneumonia. Good response was obtained in 16 cases of pneumonia, in 1 case of lung abscess, in 2 cases of acute bronchitis, in 1 case of cholecystitis and in 1 case of UTI. Fair response was obtained in 1 case of lung abscess. Poor response was obtained in 1 case of chronic bronchitis and in 1 case of UTI.
3) As side effect, rash was seen in 2 cases and elevation of transaminase was seen in 3 cases.
