1980 Volume 28 Issue Supplement6 Pages 341-353
Cefoperazone (CPZ, T-1551) has been studied in clinic, and the following results were obtained.
1) CPZ was injected intravenously at a dose of 1, 000 mg into the 5 patients with various renal functions, and its concentrations in the blood and urine were determined. The CPZ concentration in the blood was 90 μg/ml 1 hour later in uremic cases. In contrast, 3 cases with Ccr. above 32.9 ml/min showed lower concentrations which had no appreciable deviations. Regardless of the degree of renal dysfunction, however, there was little difference between the CPZ concentrations in the blood in all cases between 4 and 6 hours after the injection. The serum concentrations of CPZ slowly declined to an undetectable level after 24 hours.
The urinary excretions were 2.0% and 0.37% in uremic cases and were below 30% in the other cases by 6 hours later.
2) CPZ was administered to 42 patients: 19 respiratory tract infection, 2 pyothorax, 11 biliary tract infection, 4 urinary tract infection, 1 myositis purulenta, 2 sepsis, and 3 fever of unknown origin.
Clinical results were excellent in 4, good in 21, fair in 2, poor in 7, and undetermined in 8.
Each patient sufferer from one of the following adverse reaction: drug fever, pain and diarrhea. The elevation of GOT was observed in 3 patients, the elevation of GPT in 4, the elevation of the bilirubin in 1, the decrease on Ht in 3, leucopenia in 2 and eosinophilia in 4, but no severe side effects caused by CPZ were observed.
