1980 Volume 28 Issue Supplement6 Pages 385-389
On a new cephalosporin derivative, cefoperazone (CPZ, T-1551), several experiments were performed. Antibacterial activity of CPZ against clinical isolates of gram-negative bacilli was excellent regardless of difference of species. The correlation of MICs between CPZ and CEZ or CTX showed that activity of CPZ exceeded the former but was somewhat inferior to the latter.
The serum, biliary and urinary levels of CPZ injected to rats treated with CC14 to cause acute and chronic liver injuries were determined comparing with normal rats. In CC1, treated rats, biliary excretion reduced in proportion to the increasing of urinary excretion. Only the serum level of chronically injured rats was higher than the other two groups.
Clinically CPZ was given to four cases. Bacteriuria due to Pseudomonas aeruginosa in a patient with indwelling catheter responded well. As a result, one case of postoperative cholangitis was good, and two patients with pyrexia of unknown origin who had been suspected of sepsis were fair. In one case eruption appeared after the eighth day of treatment. After the cessation of administration, it subsided gradually. The abnormal finding was not observed on the clinical laboratory tests.
