1980 Volume 28 Issue Supplement6 Pages 467-474
Laboratory and clinical studies on cefoperazone (CPZ, T-1551) were performed and the following results were obtained.
1) Tissue concentrations in rats reached peak values at 30 minutes after subcutaneous administration and they were the following order of kidney, liver, serum and lung. Afterwards they decreased rapidly, and 4 hours later CPZ was not detectable in all organs except kidney.
2) In a patient with chronic renal insufficiency (under hemodialysis), serum concentration of CPZ, 24 hours after intravenous administration of 1g, showed high value (27μg/ml).
3) Clinical trial of CPZ were performed in 16 patients, 10 with moderate and serious respiratory tract infections, 3 with biliary tract infections and 3 with urinary tract infections. The treatment was markedly effective in 2, moderately effective in 10, ineffective in 2 and unevaluable in 2. Except for skin eruption observed in one case, no other adverse or side effects were noticed.
