Abstract
Bactericidal activity of cefazolin, cefoxitin and cefmetazole against clincial isolates of E. coil and K. pneurnoniae was investigated:
The mean geometric MICs of cefmetazole against 200 strains each of the test organism were lowest, followed in descending order by those of cefazolin and cefoxitin. The killing activity at the fixed concentrations of 5 and 50μg/ml of cefazolin and cefmetazole was almost the same, but was stronger than that of cefoxitin.
In the kinetic model under the conditions simulating serum levels of the two drugs in humans after i. v. injection (1g), cefazolin was strongest in bactericidal activity of the three drugs. The results indicate that the highest and most prolonged serum concentrations of cefazolin refrected the strong bactericidal activity and the longest inhibition period of the bacterial regrowth.
