Abstract
In vitro and in vivo antibacterial activities of KW-1070 against gram-positive andgram-negative bacteria were summarized as follows.
(1) KW-1070 has a broad spectrum of antibacterial activity against gram-positive andgram-negative bacteria. The MICs of KW-1070 were similar to those of KM againstaminoglycoside-susceptible strains, slightly less than those of GM or DKB.
KW-1070 had a strong activity against S. marcescens but a weak activity against P. aeruginosa.
(2) KW-1070 was active against GM-resistant S. marcescens and GM-resistant P. aeruginosa, and showed no cross-resistance with GM.
3) MBCs of KW-1070 were found to be near MIC values and KW-1070 acted bactericidally.
(4) KW-1070 was active against many aminoglycoside-resistant bacterial strains withaminoglycoside-inactivating enzymes, particularly AAC (6'), AAC (2'), AAD (2'') and APH (3'), except AAC (3)-I.
(5) The combination of KW-1070 with PIPC, CBPC or APPC acted synergistically in vitro against P. aerugtnosa.
(6) The in vivo activities of KW-1070 in mice infected with S. aureus, E. coli, Proteus sp. and S. marcescens were more favorable than those of AMK and KM.
