Abstract
1) Tetarological studies (rats)
KW-1070 was administered intramuscularly at doses of 25, 110 and 500 mg/kg to pregnant Wistar strain rats from day 7 through 17 of pregnancy.
2) Teratological studies (rabbits)
KW-1070 was administered intramuscularly at doses of 25, 90 and 300 mg/kg to pregnant rabbits from day 6 through 18 of pregnancy.
3) Fertility studies (rats)
KW-1070 was intramuscularly administered daily for 60 days to male rats starting at 5 weeks of age at doses of 25, 110 and 235 mg/kg. The compound was also administered to mature female rats for 22-30 days at the same dose levels. After administrations, male and female rats of the same dosage group were randomly cohabitated for mating. Administration of the compound was continued during this period and further until day 7 of pregnancy in mated female rats.
4) Peri-and postnatal studies (rats)
KW-1070 was intramuscularly administered daily from day 17 of pregnancy until day 21 of lactation at the same doses as in fertility studies.
The main changes observed in the above studies were renal damages and bad general conditions of parent animals which were treated at high doses of KW-1070. No significant and dose-related changes were observed in mating and pregnant abilities of parent animals, in malformation in fetuses, and in growth, mobilities and reproductive functions of newborn animals.
