Abstract
The placental transfer and transition into milk of KW-1070, a new aminoglycoside antibiotic, have been studied with 14C-KW-1070 administered intramuscularly in the pregnant snd lactating rats, respectively.
The level of 14C-KW-1070 in the umbilical cord blood was 5.4% of the peak maternal blood level and the radioactivity was eliminated slowly. At the peak fetus level (1 hour after administration), the radio activity transferred into the fetuses was found to be 0.6% of the dose.
14C-KW-1070 was distributed into the uterus, ovary and censistently into the fetal membrane.
14C-KW-1070 was excreted into milk, but the concentrations of radioactivity in milk did not exceed the maternal peak blood level.
