Abstract
The nephrotoxicity of KW-1070 was examined in rabbits, comparing with that of amikacin.
The rabbits were placed in individual cages and given only “okara” without water. Each of two aminoglycosides was administrated intramuscularly to three rabbits at a dose of 150 mg and 300 mg/kg/day for 10 days. The rabbits injected 150 mg/kg/day of KW-1070 or amikacin did not cause marked proteinuria, hematuria, increase in serum creatinine and proximal tubular damage in light microscopy. On the other hand, some of rabbits injected 300 mg/kg/day recognized marked proteinuria and hematuria. Serum creatinine increased significantly in a rabbit injected amikacin, while it did not increase in the all rabbits injected KW-1070. The proximal tubular damage was more remarkable in the amikacin-injected group than in the KW-1070-injected group.
For the clinical evaluation of KW-1070, the drug was intramuscularly administrated to 2 patients of cerebrovascular disease with pneumonia and 2 patients with acute pyelonephritis. The patients received KW-1070 in a dose of 400 mg/day for 8 to 14 days. Three patients responded well to the therapy. No side effect was observed in any patients.
