Abstract
The in vitro antimicrobial activity of fortimicin, a new aminoglycoside antibiotic, and its absorption and elimination were studied in three subjects.
The antibiotic was found to be less active against E. coli and P. aeruginosa than gentamicin. However, it demonstrated a moderate activity against gentamicin-resistant Serratia app., as MICs of gentamicin were ≥50μg/ml, while MICs of this antibiotic were 6.3-12.5μg/ml.
The serum concentrations in three healthy volunteers after intramuscular injection of 200mg fortimicin averaged 20μg/ml at 30 min. and declined with the biological half life of 1.4 hours. Mean total amount of the antibiotic eliminated in urine within 8 hours corresponded to 62.7% of the administered dose.
