Abstract
The effects of KW-1070 on the central and peripheral nervous systems were investigated in comparison with those of kanamycin (KM) and ribostamycin (RSM). The following results were obtained.
1. Like KM and RSM, intramuscular or intravenous injection of large doses of KW-1070 in mice and rats caused behavioral changes as inhibition of somatic activities induced by relaxation of skeletal muscle and sedation.
2. KW-1070 had no effects on spontaneous motor activity in Animex method, pentobarbital anesthesia, drug and electric stimulation induced convulsions, body temperature, responses to pain stimuli, spontaneous EEG, EEG arousal responses, spinal reflexes and local anesthesia.
3. Like KM and RSM, KW-1070 slightly depressed twitch responses of the tibialis anterior muscle and diaphragm to nerve stimulation.
4. Contractile responses of nictitating membrane to preganglionic stimulation of superior cervical ganglion and to injection of adrenaline were slightly depressed by large doses of KW-1070.
From these results, it was concluded that the effects of KW-1070 on the central and peripheral nervous systems were slight and nonpecific, similar to those of KM and RSM.
