1982 Volume 30 Issue 11 Pages 1270-1277
Fusobacterium (43 strains) isolated from human oral cavity, including 24 strains of Fusobacterium nucleatum and 19 strains of Fusobacterium sp., were tested for susceptibility against 34 antibacterial agents. Minimum inhibitory concentration (MIC) were determined by agar dilution method with GAM agar as a basal medium.
The distribution pattern of MIC showed single peak in most of drugs tested. Both of F. nucleatum and Fusobacterium sp. were very susceptible to agents except aminoglycosides and chemotherapeutics. Penicillin G, cephapirin, hetacillin, amoxicillin, ampicillin, piperacillin, cephalothin and cefazolin were markedly effective, and 90% of the strains were susceptible at MIC<0.1μg/ml. 90% of the strains were inhibited at MIC 0.1-1.0μg/ml of cloxacillin, methicillin, carbenicillin, cephaloridine, cephalexin, cefmetazole, lincomycin, minocycline, doxycycline, tetracycline and chloramphenicol. In the concentration of 1.0-10μg/ml of mecillinam, erythromycin, mitomycin C, polymyxin and rifampicin, and 10-100μg/ml of cephaloglycin and colistin, 90% of the strains were inhibited. Aminoglycosides, gentamicin, dibekacin, streptomycin and fradiomycin, and chemotherapeutics, nalidixic acid, piromidic acid, pipemidic acid and sulfamethoxazole-trimethoprim, were not so effective as other agents and could not inhibit 90% of the strains at MIC> 100μg/ml.
