1982 Volume 30 Issue 11 Pages 1286-1296
In this study, AM-715 was administered to 13 typhoid patients and 12 asymptomatic typhoid carriers.
Of the typhoid patients 8 cases were adults and the remaining 5 cases were children. All of the carriers were adults, and in 4 cases gall stone were observed.
Daily doses of AM-715 were administered to the adult typhoid fever patients: 1, 600 to 3 patients and 2, 000 mg to the other. Three of the children were administered 1, 200 mg and 2 were given 1, 600 mg of the drug. Except in the case of one adult patient who showed no sign of improvement with the administration of the drug, duration of the treatment extended over 14 days. Clinical and bacteriological effects were observed in all cases with the exception of the above-mentioned case.
For the typhoid carriers, daily doses of the drug were: 1, 200 mg in one case, 1, 600 mg in 10 cases and 2, 000 mg in one. Treatment was continued for over 14 days in these cases too. One female carrier relapsed 5 months after her discharge.
No major adverse reaction was recognized, but the following slight abnormalities occured in laboratory findings: elevated transaminase activity in 2 cases, eosinophilia and elevation of serum bilirubin value in one case, granulocytopenia in one case, granulocytopenia with thrombocytopenia in one case and thrombocytopenia in one case. One of the cases of thrombocytopenia still showed abnormality after 2 weeks, but in the other case abnormalities disappeared in a week.
The results of further follow-up study of 8 cases formerly reported were also described.
