THE INACTIVATION OF NETILMICIN MIXED WITH CARBENICILLIN OR SULBENICILLIN

Abstract

A 10μg/ml of netilmicin was incubated at 37°C for 48 hours with the 200μg/ml or 500μg/ml of carbenicillin and sulbenicillin, respectively. The residual activity of netilmicin in these mixtures was measured by bioassay. Netilmicin kept its activity completely even after 24 hours of the incubation and was slightly inactivated after 48 hours. The residual activity of netilmicin after 48 hours was 72 and 71% respectively in the mixture with 200μg/ml of carbenicillin and sulbenicillin, and 58 and 52 in the mixture with 500μg/ml of each penicillin.