COMPARATIVE NEPHROTOXICITY OF NETILMICIN, GENTAMICIN AND DIBEKACIN IN RABBITS

Abstract

The nephrotoxicity of netilmicin in rabbits was examined, comparing with that of gentamicin and dibekacin. In the first experiment, the rabbits were placed in individual cages, permitted free access to tap water and pellet food for rabbit. Each of three aminoglycosides was given intramuscularly to three rabbits at a dose of 100 mg/kg/day for 10 days. These three drugs did not cause marked proteinuria, he, naturia, increase in serum creatinine and proximal tubular damage in light microscopy. In the second experiment, the rabbits were given only “okara” without water. The abnormality in urinalysis, serum creatinine and proximal tubules was more remarkable in the second experiment than in the first experiment. However, the netilmicin-injected group revealed significantly less nephrotoxicity than the other groups.