1982 Volume 30 Issue Supplement2 Pages 184-190
Five patients with respiratory tract infections and 12 with urinary tract infections were treated with BRL25000 (amoxicillin and clavulanic acid in the ratio 2:1). The effective rates were 75.0%(3/4) and 66.7%(8/12), respectively. The overall clinical effective rate was 68.8%(11/16).
Classifying the causative organisms by strain BRL25000 was effective in the treatment of 2 out of 5 cases of Klebsiella sp. 7 out of 7 cases of E. coli and 1 out of 2 cases of H. parainfluenzae. The Klebsiella sp. isolates from the two patients that responded to BRL25000 therapy were more susceptable to BRL25000 than AMPC in MIC tests.
Side effects were observed in 2 patients consisting of dizziness and nausea. Laboratory findings, transient elevation of BUN and S-creatinine were seen in one patient.
