EFFECT OF CEFOTIAM ON A RABBIT UTERINE INFECTION MODEL

Abstract

We carried out an examination of the therapeutic effects of Cefotiam (CTM) against uterineinfectious diseases by using a rabbit experimental model of intra-uterine infection. Cefazolin (CEZ) was used as the standard antibiotic in each test.
1) MIC of CTM and CEZ against 10⁶cells/ml of E. coli PYO-252 strain, which were inoculated into rabbit uteri, were 0.1μg/ml and 3.1μg/ml, respectively.
2) Plasma level of both antibiotic after a single intravenous injection quickly fell. However, 60 minutes after injection, the concentration of CEZ in plasma was a little higher than that of CTM. The concentration of CEZ in the uterine tissue was 3 to 5 times that of CTM.
3) In vivo therapeutic examination was performed. By the injection of 60mg/kg/day of CTM for 4 days, the inoculated E. coli disappeared and almost no pathological findings were recognized in the inoculated uterine horn. The minimal effective dose measured by the disappearance of E. coli was 60mg/kg/day of CEZ and 30 mg/kg/day of CTM. Thus CTM was as effective as CEZ at half the dose.
Accordingly, it is strongly suggested that CTM has a use in the therapy of the uterine infectious diseases.