1983 Volume 31 Issue 11 Pages 1047-1054
The effect of β-lactam antibiotics on the Sub-Minimum inhibitory concentration (Sub-MIC) in human serum and in various animal serums were studied.
In nutrient broth (NB) and in various animal serums, piperacillin (PIPC), cefoperazone (CPZ) and cefbuperazone (T-1982) showed bacteristatic or bactericidal activity, and difference in bactericidal activity was observed among species of animal. PIPC provided stronger activity in rabbit serum and in human serum than in NB. This was supported by the observation on phase contrast micrographs and electron micrographs.
Carbenicillin (CBPC), cefazolin (CEZ) and cefmetazole (CMZ) slightly inhibited the growth of bacteria in NB, but they hardly showed bactericidal activity in the serums.
Bactericidal activity of any of above β-lactam antibiotics in heat-treated serum was inferior to that in fresh serum, which suggested the relevancy of the complement etc.
