CEFTAZIDIME-PHARMCOKINETICS AND CLINICAL EXPERIENCES IN THE AGED PATIENTS

Abstract

Serum concentrations of ceftazidime (CAZ, SN401) were determined after intravenous injection of 1g of the drug in 4 aged patients.
The serum level at 5 minutes after injection reached over 100μg/ml. Serum half lives in 3 patients whose serum creatinine levels were below 1.5 mg/dl were 2.5, 3.5 and 5.1 hours, respectively. The patient with impaired renal functions (S-Cr: 2.5mg/dl, Ccr: 11.6) showed prolonged T_1/2 of 12.2 hours.
Ceftazidime was given to 14 patients (3 with pneumonia, 1 with bronchiolitis, 6 with pyelonephritis, 3 with biliary tract infections, and 1 with decubital infection). Thirteen responded satisfactorily.