Abstract
Ceftazidime (CAZ, SN401) was administered to 14 patients with surgical infections and to one patient for prophylaxis of postoperative infections after the total surgery of rectal cancer, and its clinical efficacy was studied.
The drug was given either by intravenous bolus injection or by 500ml drip infusion at a daily dose of 2-4g divided into twice or 3 times. The 14 infections comprised acute peritonitis in 7 cases, biliary tract infections in 6 cases and periproctal abscess in 1 case. The clinical response was found to be good in 13 cases (efficacy rate: 93%) and fair in 1 (7%). During therapy with CAZ, side effects which were presumed to be attributable to CAZ were observed in 4 cases, i. e. diarrhea in 2 cases, eruption and drug fever each in 1 case. All of these symptoms, however, were improved immediately after the withdrawal of the drug.
On the 9 th day after the surgery, 1g of CAZ was given by bolus injection intravenously to one patient with T-tube intubated and the bile concentrations were hourly determined. The peak level of 35.5μg/ml was achieved 3 hours after the injection and even after 6 hours, as high as 12μg/ml of bile concentration was sustained.
