1984 Volume 32 Issue 8 Pages 511-516
The pharmacokinetics of dibekacin concerning the renal accumulation were studied in the normal rabbits and infected rabbits whose right kidneys were caused dysfunction by the ascending infection with Escherichia coli O-124.
The elimination half-lives (T 1/2β) were 155min. in the infected rabbits and 73.4min. in the normal rabbits. There was no difference in the renal clearances, cumulative urinary excretion amounts, and renal levels of dibekacin between the right and the left kidneys in the normal rabbits. In the infected rabbits, however, the renal clearances, the cumulative urinary excretion amounts and the renal levels of dibekacin in the ipsilateral kidneys were about 80% of those in the contralateral kidneys. There was a good linear relationship between the ratio of the renal dibekacin levels of the right to the left kidneys and the ratio of the cumulative urinary excretion amounts of the right to the left kidneys. It is considered that the renal accumulation of dibekacin is proportional to the amounts of the drug excreted from the kidneys into urine.
