1984 Volume 32 Issue Supplement2 Pages 261-265
TA-058, a new semisynthetic penicillin derivative developed by Tanabe Seiyaku Co. Ltd., has a wide spectrum of activity against gram-positive and gram-negative bacteria.
TA-058 was used in the treatment of 7 cases of respiratory infectious disease: 3 cases of bronchiectasis, 3 cases of respiratory infectious tract infection with bronchial asthma and pulmonary emphysema and one case of pneumonia. TA-058 was administered by intravenous drip infusion at a dose of 1.0 g twice daily for 5 to 14 days except in one case who had an adverse effect.
Response was excellent in 5 cases, good in one case and not determined in one case because of adverse reaction.
Adverse reaction noted was eruption and eosinophilia in one patient but in the other 6 cases, no side effects were observed during the course of the administration.
From the results of the investigation it is concluded thact TA-058 is as effective as ampicillin treating respiratory infectious disease.
