ANTIBACTERIAL ACTIVITY OF TA-058 AGAINST ANAEROBIC BACTERIA

Abstract

Bacteriological evaluation to anaerobic bacteria was made on TA-058, a new penicillin, and the following results were obtained.
TA-058 had a broad antibacterial spectrum against anaerobic bacteria and at 1.56μg/ml inhibited the growth of many test species except B. fragilis, B. thetaiotaomicron, B. disiens, B. bivius, E. lentum and C. difficile. The antibacterial activity of TA-058 against these bacteria was more potent than that of SBPC, CBPC, and TIPC but was less potent than that of ABPC.
TA-058 was as effective as CFX against experimental mice infection by a beta-lactamase producing strain of B. fragilis (GAI 0558), for which MICs of TA-058 and CFX were 400 and 12.5μg/ml respectively.
TA-058, unlike ABPC, SBPC and CBPC, supressed the abnomal growth of C. difficile in caecum contens of mice.