1984 Volume 32 Issue Supplement2 Pages 435-439
TA-058, a new semisynthetic penicillin derivative, was studied fundamentally and clinically, and the following results were obtained.
1) Antibacterial results
The antibacterial activity against S. aureus, E. coli, E. cloacae, K. pneumoniae and P. aeruginosa were examined, TA-058 was more active than that of CBPC but somewhat less active than that of PIPC.
2) Clinical results
TA-058 was used in the treatment of 6 cases with respiratory tract infections. The clinical results were evaluated as excellent in 3 cases, good in 2 cases and poor in one case.
3) Side effects
No side effects nor any abnormalities in laboratory findings were noticed. In conclusion, TA-058 seems to be a safe and useful drug in practice.
