1984 Volume 32 Issue Supplement2 Pages 452-462
A new semisynthesized penicillin, TA-058 for parenteral use, having broad spectrum for grampositive and gram negative bacteria and better responses has in vivo more than in vitro effect, was administered to a total of 30 patients. Those were 10 outpatient cases of acute infectious diseases of skin and soft tissues, 20 hospitalized cases of abdominal infectious diseases (15 with acute peritonitis and 5 with acute or subacute cholecystitis and cholangitis). TA-058 was given by intravenous bolus injection once a day for outpatients at a dose of 1 g and for hospitalized patients, it was given at a dose of 1 to 2 g by intravenous drip infusion twice or 3 times a day for 3 to 10 days. The clinical efficacy obtained was excellent 11 cases, good in 18 cases, fair in no case and poor in one case. Clinical adverse effect was not recognized.
Therefore, TA-058 appears to be a very useful drug that used for chemotherapy on acute peritonitis and biliary tract infection.
