1984 Volume 32 Issue Supplement2 Pages 491-501
Fundamental and clinical studies on TA-058, a newly synthesized penicillin, in the surgical field and the following results were obtained.
1) Antibacterial activity
MIC value of TA-058 was superior to CBPC against E. coli isolated from surgical wound but slightly inferior to PIPC. Antibacterial activity against Klebsiella was apt to resistance.
2) Biliary excretion
Bile concentrations of TA-058 were measured in 2 patients. Those of peak level after intravenous administration of 1g were 81μg/nil and 23μg/ml, which showed low level becauce of severe patients.
Bile excretion of TA-058 was included in the moderate group.
3) Clinical results
TA-058 was used in 37 cases of suriicaf infections and in 2 cases of prophylactic use against postoperative infection due to acute appendicitis. The results were excellent in 7 cases, good in 22 cases, fair in 3 cases and unknown 5 cases. Rate of clinical effectiveness was 90.6%.
No side effects could be found in any of cases.
