CHEMOTHERAPY OF PERITONITIS (IV) EXCRETION IN ASCITIC FLUID AND ITS CLINICAL EFFECT USING A NEW ANTIBIOTICS, TA-058
1984 Volume 32 Issue Supplement2 Pages 514-524
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1984 Volume 32 Issue Supplement2 Pages 514-524
Fundamental and clinical studies on TA-058, a new injectable penicillin compound which was derived N4-methvl-D-asparacrinyl residue on side chain of amoxicillin. performed to abdominal infections, especially on peritonitis, and following results were obtained.
1) The transfer into ascitic fluid and serum concentration were investigated against 2 patients with peritonitis. The peak concentration of ascitic fluid was observed in 1-2 hours after intravenous administration of 1.0 g of TA-058, 66.0μg/ml and 74.0μg/ml, respectively. High concentration (20.0μg/ml, 18.2μg/ml) of ascitic fluid was maintained even after 6 hours.
2) TA-058 was treated in total of 27 cases with intra-abdominal infection; 18 cases of peritonitis, 6 cases of abdominal abscess and 3 cases of postoperative wound infection of the abdominal wall. The clinical efficacy was excellent in 5 cases, good in 13, fair in 4 and poor in 3, with an effectiveness rate of 72.0%.
3) In bacteriological effects, the treatment provided eradication of E. coil, S. faecalis and Bacteroides sp., while P. aeruginosa partially persisted.
4) No serious side effects were observed.
