1984 Volume 32 Issue Supplement2 Pages 543-552
The experimental and clinical studies on TA-058 were carried out. The results were as follows.
(1) Antibacterial activity
TA-058 has broad spectrum for GPC and GNR as well as other penicillins.
(2) Clinical effects
Two of three patients with acute simple pyelonephritis administered with daily doaes of 2 g of TA-058 for 5 days showed excellent efficacy. MIC of E. coli with one poor case was >100 μg/ml. This result has shown the high efficacy of TA-058 for acute simple pyelonephritis. Eighteen patients with chronic complicated urinary tract infections were intravenously administered with daily doses of 2 g or 4 g of TA-058 for 5 days. Clinical response was excellent in 6 cases, good in 4 cases and poor in 8 cases. The efficacy rate was 56%. According to classification by type of complicated U.T.I., TA-058 has good efficacy in 4 th group.
(3) Side effect
TA-058 has very low toxicity. In this study, no abnormal findings were observed in hemogram, liver and renal functions.
