1984 Volume 32 Issue Supplement2 Pages 588-597
Laboratory and clinical traials of TA-058, a new semi-synthetic penicillin, were performed and following results were obtaind.
1) A peak prostatic tissue level of 43.5 μg/g was achieved in prostatauxe after administration of 1 g.of, TA-058 intravenously and its ratio to the mean serum level was 27.0%.
2) The morphological alteration of S.warneri in urine exposed to TA-058 showed various situation with swelling, aggregation and normality.
In that of E. coli, TA-058 induced filamentation of the cells at low concentrations. Spheroplasts were formed with elevation of the concentration, and the filamentous cells were lysed.
3) The clinical rate of effectivness for 23 cases of acute simple cystitis was 91.3%, and that of 13 cases of complicated urinary tract infections was 38.5%.
4) Any serious side effects and abnormal laboratory findings were not observed.
